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Garlic Oil May Reverse
Diabetes-Linked Heart Disease
Nutritive Super Food Contains Natural Antioxidants,
Carotenoids and Enzymes Beneficial For Cardiovascular
Health
Problems in heart function related to diabetes may be improved
by supplementation with garlic oil, according to new laboratory-
controlled research.
The study, published in the Journal of Agricultural and Food
Chemistry, suggests that cardiac abnormalities induced by
diabetes can be reversed in as little sixteen days of garlic oil
supplementation.
“Our results show that garlic oil supplementation for laboratory
subjects leads to several alterations at multiple levels in hearts
including cardiac contractile functions and structures, myosin
chain gene expressions, oxidative stress, and apoptosis and
related signaling activities,” wrote the researchers from the
China Medical University in Taiwan.
Diabetic Risk
Diabetes mellitus is a major risk factor in the development
of cardiovascular disease, accounting for 80 percent of all
diabetic mortality.
Damage to cardiac function is well documented in diabetes,
and death from heart disease is known to be between two
and four times higher in patients with diabetes than those
without diabetes.
Garlic (Allium sativum) has been suggested to exhibit several
health benefits, including inhibiting enzymes involved in lipid
synthesis, decreasing platelet aggregation, preventing lipid
peroxidation, and increasing antioxidant status.
Previous studies have suggested that garlic oil could protect
the cardiovascular system. However, the mechanism by which
garlic oil protects diabetes-induced cardiomyopathy is unclear.
The new study investigated the effects of garlic oil on the
cardiac function of laboratory subjects induced with diabetes.
Dose-Dependent Reversal
Diabetes related cardiac dysfunctions were dose-dependently
relieved through administration with garlic oil.
The researchers observed diabetes to significantly decrease
heart rate, which was dose-dependently reversed to control
levels by garlic oil feeding.
Garlic oil was also reported to reverse the effects of diabetes
on cardiac output and the hearts pumping capacity in a dose
dependant manner.
Diabetic subjects also showed significantly decreased levels
of myosin heavy chains, key contractile proteins in the heart,
which were dose dependently attenuated by garlic oil.
Significant Protective Potential
The researchers concluded that “garlic oil possesses
significant potential for protecting hearts from diabetes-
induced cardiomyopathy.”
Adding that garlic oil reduces oxidative stress and counteracts
activations of up-regulated cell suicide signals, and as such
could be considered to possess potential in protecting hearts
from diabetic cardiomyopathy.
“All of these phenomena might be associated with the
antioxidant potential of garlic oil, which is attributed to the
presence of organosulfur compounds that modulate the
cardiac antioxidant activity,” said the authors.
They added that further studies were needed, “to investigate
the individual garlic oil constituent compounds on improving
diabetic cardiac dysfunction.”
Source: Journal of Agricultural and Food Chemistry
(Published online)
“Cardiac Contractile Dysfunction and Apoptosis”
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