CoQ10 (Coenzyme Q10) Benefits

Coenzyme Q10 Supplements
May Protect Against Obesity Problems

When it comes to CoQ10 benefits, findings from a new laboratory study
suggest that Coenzyme Q10 (CoQ10) supplements may protect or
slow down the development of fatty liver related to obesity.

Laboratory subjects fed a high fat and fructose diet and supplemented with
CoQ10 had decreased levels of inflammatory and metabolic stresses markers
in their livers than mice just fed the high-fat diet, according to findings published
in Biochemical Pharmacology.

The supplements did not have any effect on obesity levels or levels of oxidized
fat products in other tissues, added the researchers from the Catholic University
of Leuven, Germany.

CoQ10 has properties similar to vitamins, but since it is naturally synthesized
in the body it is not classed as a vitamin. It is also known as ubiquinone because
of its 'ubiquitous' distribution throughout the human body.

The coenzyme is concentrated in the mitochondria, considered the 'power plants'
of the cell and plays a vital role in the production of chemical energy by participating
in the production of adenosince triphosphate (ATP), the body's energy fuel.

There is an ever-growing body of scientific data that shows substantial health
benefits of CoQ10 supplementation for people suffering from angina, heart attack
and hypertension. The nutrient is also recommended to people on statins to
off-set the CoQ-depleting effects of the medication. Other studies have reported
that CoQ10 may play a role in the prevention or benefit people already suffering
from neurodegenerative diseases.

The new study, suggests the molecule may also improve liver health.

The Leuven-based researchers, in collaboration with scientists from the
University of Witten/Herdecke in Germany, fed laboratory subjects a control diet,
a high-fat diet with fructose, or the same high-fat, fructose diet plus CoQ10
supplements for eight weeks.

The subjects fed the high-fat, fructose diet consumed more energy, and showed
higher fat mass development, fasting blood glucose and abnormally high insulin levels.

The high-fat, fructose diet also promoted gene expression in the liver for reactive
oxygen species production, inflammation, and metabolism, said the researchers.

In the CoQ10 supplemented animals, however, the researchers noted a decrease
in gene expression for the inflammatory and metabolic stresses markers.

“We propose, in view of our study, that CoQ10, when given orally, is able to target
the liver tissue, and to lessen inflammatory stress associated with obesity in mice
in this tissue, independent on any action on lipid peroxidation,” wrote the researchers.

Source: Biochemical Pharmacology

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